Oral administration of pyrophosphate inhibits connective tissue calcification


Various disorders including pseudoxanthoma elasticum (PXE) and generalized arterial calcification of infancy (GACI), which are caused by inactivating mutations in ABCC6 and ENPP1, respectively, present with extensive tissue calcification due to reduced plasma pyrophosphate (PPi). However, it has always been assumed that the bioavailability of orally administered PPi is negligible. Here, we demonstrate increased PPi concentration in the circulation of humans after oral PPi administration.

EMBO Molecular Medicine (2017) e201707532

My research interests include Graph Theory, Computational Geometry, and Algorithms